The libraryMetabolism
Semaglutide
Average loss runs about 15% of body weight, and most of it comes back after you stop.
Also called Ozempic, Wegovy, Rybelsus
Who it's forAny man carrying real weight who's lost it and regained it more times than he'll admit.
The item
Three squares: proven in human trials. Two: a strong signal. One: early human data. Striped: the trials disagree.
Start today
- Get the 0.25 mg starter pen from a pharmacy and put three lifting sessions in the calendar the same week.
Why it works
Semaglutide is the weight-loss drug that changed the conversation. It is a lab-made version of the gut hormone that tells your brain you're full. Under the names Ozempic and Wegovy, it made appetite itself the target.
Activates the GLP-1 receptor: the meal-is-done message the gut sends the brain.
Delays gastric emptying, so the meal you ate keeps counting for longer.
Damps the hypothalamic circuits behind constant eating thoughts.
It slows your stomach's emptying and quiets the brain circuits that generate food noise. Most people describe the effect simply: they stop thinking about eating.
The doses the studies used
| Study / Context | Route | Dose | Duration |
|---|---|---|---|
| SUSTAIN (1-10) | Subcutaneous injection | 0.25 mg weekly (initiation), adjusted to reach 0.5 mg or 1.0 mg weekly | 30-104 weeks |
| STEP (1-5) | Subcutaneous injection | 0.25 mg weekly to start, stepped up over 16 weeks to 2.4 mg weekly | 68-104 weeks |
| SELECT | Subcutaneous injection | Target dose 2.4 mg weekly (stepped up from 0.24 mg) | Mean 39.8 months |
| FLOW | Subcutaneous injection | Target dose 1.0 mg weekly (stepped up from 0.25 mg) | Median 3.4 years |
| STEP UP | Subcutaneous injection | Target dose 7.2 mg weekly (stepped up from 0.25 mg) | 72 weeks |
| PIONEER (1-10) | Oral tablet | 3 mg, 7 mg, or 14 mg daily (taken fasting with up to 4 fl oz, 120 mL water) | 26-78 weeks |
Where it fits
Semaglutide is a move in 16 protocols. Each one opens the plan it sits in.
- Use Weight-Loss Medicine Right
- Stop Binge Eating
- Keep the Fat Off
- Keep the Fat Off After GLP-1
- Lose Fat and Build Muscle
- Earn Your Abs
- Bring Down Your Blood Sugar
- Lose Fat
- Quit Smoking and Vaping
- Fix Your Knee Pain
- Stay Sober
- Stop Eating at Night
- Drink Less
- Keep Your Muscle on GLP-1
- Add Healthy Years to Your Life
- Stack TRT Right
What people say
Here is what doctors, influencers and men online say about Semaglutide, word for word.
Experts
Clinicians, authorities
“in rare cases pancreatitis and inflammation of the pancreas and these drugs do carry a black box warning for a rare type of thyroid cancer”
“while these medications have shown promise for individuals to lose 10 to 20% of their weight if they are overweight or obese, it's still important to factor in that there are legitimate risks”
“most of the more serious side effects of glp1 drugs are on the rare side most people who take these medications will not get pancreatitis”
Gurus
Podcasts, channels, influencers
“A major clinical trial of semaglutide in adults showed an average weight reduction of around 15% when paired with an adjusted diet and exercise routine compared to a placebo group”
“they essentially really reduce the appetite which goes to show you that and people lose weight like a lot of weight and they keep it off”
“the newer compounds soon to overcome some of those side effects, such as muscle loss”
Regular people
Forums, reviews, comments
“I've lost 16lbs and if I'd known back in January I'd lose over a stone by mid-March I'd have been thrilled.”
“It's temporary and reversible and shouldn't be used as evidence of decreased cardiovascular function. My capacity for running has increased dramatically since starting semaglutide.”
“Wegovy (Semaglutide) has an average rating of 3.8 out of 5 from 491 reviews on WebMD.”
Questions
- How do I know my Semaglutide is genuine?
- Get it on a prescription, from a pharmacy.
The studies
Every study behind this page.
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 DiabetesPubMed, PMID 27633186
- Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUPubMed, PMID 28110911
- Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7)PubMed, PMID 29397376
- Once-Weekly Semaglutide in Adults with Overweight or ObesityPubMed, PMID 33567185
- Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trialPubMed, PMID 33667417
- Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in PubMed, PMID 33625476
- Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With OverwPubMed, PMID 33755728
- Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extensionPubMed, PMID 35441470
Words on this page
- PMID
- A study's ID number in PubMed, the public index of medical research.
Take the shot if you're genuinely obese, and lift the whole time you're on it.
Emergency: call 911.
I am not a doctor. This is not medical advice. This is self-education. Talk to a physician who has your history before you change anything.