Keep the Fat Off After GLP-1

Coming off GLP-1

Also called Stopping semaglutide or tirzepatide, Stopping GLP-1 shots, GLP-1 rebound, Weight gain after stopping

3 min plan49 min with every studyUpdated Sep 27, 2026

Who it's forA man, 18 to 45, coming off semaglutide or tirzepatide, who wants to keep the weight off.

When to see a doctor

On the drug for type 2 diabetes, or your sugar was high before it: never stop without your doctor. Very tired, peeing more, thirsty all the time or losing weight without trying: see your doctor.
On it after a heart attack or stroke, or for sleep apnea or liver disease: stopping is a decision for your doctor, because the drug treats those too.
Weight climbing fast despite the plan, or you take steroids, antidepressants or beta blockers, or have a thyroid problem: speak to your doctor.
Worrying about your weight or body shape a lot of the time, or eating in secret: see your doctor soon.
Breathing that stops and starts in your sleep, gasping, and tired all day: see your doctor about sleep apnea.
Severe pain in your stomach or back that does not go away while on the drug: stop it and get seen that day. It can be pancreatitis.

I am not a doctor. This is not medical advice. This is self-education. Every dose on this page is the one a trial or a label used, quoted from the source. It is not a prescription. Never change or stop a prescribed medicine without your doctor. See a doctor about any warning sign on this page, and before anything in the With a doctor group.