The libraryMetabolism
Calorie Restriction
The deficit takes lean mass, bone and testosterone at the same time it takes the fat.
Also called Caloric Restriction, CR, Energy Restriction, Dietary Energy Restriction
Who it's forAny man dieting who thinks eating less is the whole plan.
The item
Three squares: proven in human trials. Two: a strong signal. One: early human data. Striped: the trials disagree.
Start today
- Write an end date on your cut today and book the lifting sessions that carry you to it.
Why it works
The effect comes less from weight loss than from the signaling state the body is in. A steady energy deficit lowers insulin and IGF-1, quiets mTOR, and switches on AMPK and autophagy. That shifts cells from growth toward maintenance and repair. That switch, not the scale, is what the longevity research is really about.
Where it fits
Calorie Restriction is a move in 6 protocols. Each one opens the plan it sits in.
What people say
Here is what doctors, influencers and men online say about Calorie Restriction, word for word.
Experts
Clinicians, authorities
“But calorie restriction is probably not for everyone. Our findings are important because they provide evidence from a randomized trial that slowing human aging may be possible.”
“Therefore, bone loss at clinically important sites of osteoporotic fractures represents a potential limitation of prolonged CR for extending life span.”
“The calorie-restriction intervention did cause slight declines in bone density, lean body mass, and aerobic capacity (the ability of the body to use oxygen during exercise).”
Gurus
Podcasts, channels, influencers
“Clinical trials suggest that caloric restriction may offer similar health benefits to humans, but the studies have been too short to provide conclusive results.”
“We, the authors, conclude that the evidence as it stands weakly supports the conclusion that CR modestly extends human life.”
“These reproductive side effects are not to be taken lightly; in addition to being generally unpleasant, there are long-term consequences to maintaining a prolonged state of sex hormone suppression”
Regular people
Forums, reviews, comments
“I've found that with time, a sensation of 'hungry' is just another sensation that my body reports - it's not an imperative to eat.”
“CR as a life extension method in non-obese humans remains unsupported; much relevant evidence suggests that it will not work and may be harmful.”
“Basically I felt like I was on the edge of a cold all the time. Anything activity like cycling was utterly draining. The world was very dull and grey indeed.”
The studies
Every study behind this page.
- Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled TrialsPubMed, PMID 32751664
- The effect of caloric restriction on blood pressure and cardiovascular function: A systematic review and meta-analysis of randomized controlled trialsPubMed, PMID 32675017
- Effects of dietary restriction on adipose mass and biomarkers of healthy aging in humanPubMed, PMID 27899768
- Caloric restriction in heart failure: A systematic reviewPubMed, PMID 32690177
- Is isocaloric intermittent fasting superior to calorie restriction? A systematic review and meta-analysis of RCTsPubMed, PMID 39732588
- Registered trial NCT05651620Trial registry
- Registered trial NCT07065643Trial registry
- Registered trial NCT06878989Trial registry
- Registered trial NCT05549362Trial registry
- Dietary restriction impacts health and lifespan of genetically diverse micePubMed, PMID 39385029
- Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trialPubMed, PMID 37118425
Words on this page
- PMID
- A study's ID number in PubMed, the public index of medical research.
Cut in blocks, lift heavy through it, and set the date you stop.
Emergency: call 911.
I am not a doctor. This is not medical advice. This is self-education. Talk to a physician who has your history before you change anything.