The libraryWillpower

Getting off nicotine

Varenicline plus a patch held 55.4 percent off at twelve weeks against 40.9 alone.

Also called Smoking cessation, Quitting smoking, Varenicline, Chantix, Cytisinicline, Cytisine

Who it's forAny man who's decided to stop smoking and thinks willpower is the whole plan.

The item

Three squares: proven in human trials. Two: a strong signal. One: early human data. Striped: the trials disagree.

Willpower Calm

Buffs

Varenicline roughly doubles long-term quit rates
Varenicline beats bupropion and beats the patch head to head
Bupropion beats placebo
Nicotine replacement beats placebo
A patch plus a fast-acting form beats any single form
Quitting adds years of life
Cytisinicline matches the best of them at a fraction of the nausea
Men keep quitting between week six and week twelve
Adding a nicotine patch to varenicline adds quits
Behavioral support on top of medication adds quits
Extending varenicline past the standard course prevents relapse
Mood improves after quitting rather than worsening
Cytisinicline gets men off nicotine vapes
Varenicline gets men off nicotine vapes
Matching the drug to how fast a man clears nicotine contested

Debuffs

Know firstSerious adverse events reported more often on varenicline
Know firstBupropion may add about one serious adverse event per hundred
ManageableNausea in a quarter of varenicline courses
ManageableInsomnia on bupropion
ManageableDropping out of bupropion because of side effects
ManageableFour to five kilos in the first year
ManageableSkin reactions when a patch is stacked on varenicline
MildVivid dreams on the nicotine patch
MildCraving and withdrawal through the first eight days
MildNausea, insomnia and abnormal dreams on cytisinicline

“Ask for varenicline and put a nicotine patch on top of it.”

Emergency: call 911.

I am not a doctor. This is not medical advice. This is self-education. Talk to a physician who has your history before you change anything.