The libraryCalm

Ayahuasca

The vine shuts down the enzyme that clears serotonin, and an SSRI keeps piling it on.

Also called Yagé, Yajé, Hoasca, Daime, Natem, Caapi

Who it's forAny man booking an ayahuasca retreat while he's on an antidepressant.

The item

Three squares: proven in human trials. Two: a strong signal. One: early human data. Striped: the trials disagree.

Calm Willpower Defense Focus

Buffs

Rapid reduction in depressive symptoms contested
Improved wellbeing & life satisfaction
Increased mindfulness capacities
Reduced problematic alcohol & substance use
Reduced anxiety symptoms
Reduced suicidal ideation
Reduced systemic inflammation
Improved cognitive flexibility & divergent thinking
Reduced grief severity

Debuffs

Know firstNausea, vomiting, & diarrhea
Know firstTransient blood pressure & heart rate elevation
Know firstAcute psychological distress
ManageableSerotonin toxicity when combined with serotonergic drugs
ManageableProlonged psychiatric complications
ManageableHeadache & post-session fatigue
MildManic or hypomanic episodes
MildSeizures
MildHallucinogen persisting perception disorder
MildDeaths in retreat settings
MildHarms arising from unregulated settings

“Hand over every pill you take before you drink, or don't drink.”

Emergency: call 911.

I am not a doctor. This is not medical advice. This is self-education. Talk to a physician who has your history before you change anything.